In case an experimental setup is used that physically links nucleic acids derived from distinct Rearrangements before library preparation, this field describes the mode of that linkage. All hetero_* terms indicate that in case of paired-read sequencing, the two reads should be expected to map to distinct IG/TR loci. *_head-head refers to techniques that link the 5' ends of transcripts in a single-cell context. *_tail-head refers to techniques that link the 3' end of one transcript to the 5' end of another one in a single-cell context. This term does not provide any information whether a continuous reading-frame between the two is generated. *_prelinked refers to constructs in which the linkage was already present on the DNA level (e.g. scFv).
from schema: https://github.com/airr-knowledge/ak-schema
Mappings
Mapping Type
Mapped Value
self
ak_schema:physical_linkage
native
ak_schema:physical_linkage
LinkML Source
name: physical_linkage
annotations:
nullable:
tag: nullable
value: false
description: In case an experimental setup is used that physically links nucleic acids
derived from distinct `Rearrangements` before library preparation, this field describes
the mode of that linkage. All `hetero_*` terms indicate that in case of paired-read
sequencing, the two reads should be expected to map to distinct IG/TR loci. `*_head-head`
refers to techniques that link the 5' ends of transcripts in a single-cell context.
`*_tail-head` refers to techniques that link the 3' end of one transcript to the
5' end of another one in a single-cell context. This term does not provide any information
whether a continuous reading-frame between the two is generated. `*_prelinked` refers
to constructs in which the linkage was already present on the DNA level (e.g. scFv).
from_schema: https://github.com/airr-knowledge/ak-schema
rank: 1000
alias: physical_linkage
domain_of:
- NucleicAcidProcessing
- SampleProcessing
range: PhysicalLinkageEnum